Differential gene expression of muscle-specific ubiquitin ligase MAFbx/Atrogin-1 and MuRF1 in response to immobilization-induced atrophy of slow-twitch and fast-twitch muscles
نویسندگان
چکیده
منابع مشابه
The aerobic maternal exercise increases PDK4 gene expression in slow and fast twitch muscles of rat male offspring.
Recent studies indicate that environment can modify skeletal muscle gene expression and transcriptional factors in offspring genes. Therefore, exercising can lead to changes in the gene expression of the future generations. One of the important metabolic factors is PDK4, which is known as the main factor in Pyruvate Dehydrogenase Complex (PDC). This study examined the effects of maternal exerci...
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Background and Objectives: Myocyte enhancer factor 2c activates the genes of the slow-twitch muscle, the muscle which plays role in endurance activity. Therefore, the aim of this study was to evaluate the effect of a program of intensive endurance activity on MEF2c gene expression in fast and slow twitch skeletal muscles in wistar rats. Materials and Methods: In this experimental study, 14 mal...
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Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training. Materials and Met...
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open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملSize and Proportions of Slow-Twitch and Fast-Twitch Muscle Fibers in Human Costal Diaphragm
Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller. We compared autopsy samples of costal diaphragm and vastus lateralis of healthy men with respect to fibers' size and expression of slow myosin heavy chain isoform (MyHC-1) and fast 2A isoform (MyHC-2A). ...
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ژورنال
عنوان ژورنال: The Journal of Physiological Sciences
سال: 2011
ISSN: 1880-6546,1880-6562
DOI: 10.1007/s12576-011-0175-6